disease (ad) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE
T28750	Sembragiline	RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302	MAO
	Sembragiline (EVT-302) is a selective MAO-B inhibitor for the study of Alzheimer's disease (AD).		MAO
T28441	PPI-1019	PPI1019,Apan	Beta Amyloid
	PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).		Beta Amyloid
T21956	GSK3β inhibitor II		GSK-3
	GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).		GSK-3
TP1140L	Neuropeptide Y (29-64), amide, human acetate		Neuropeptide Y Receptor
	Neuropeptide Y (29-64), amide, human acetate is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.		Neuropeptide Y Receptor
T8583	Tenilsetam	3-(2-thienyl)- (9CI),Piperazinone	Others
	Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.		Others
T8448	ZSET1446	ZSET-1446,ST-101	Calcium Channel , AChR
	ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.		Calcium Channel , AChR
T4955	Saponaretin	Isovitexin,Apigenin-6-C-glucoside	Apoptosis , Antioxidant
	saponaretin, an active component of many traditional Chinese medicines, shows various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.		Apoptosis , Antioxidant
TN1341	8-Deoxygartanin		Beta Amyloid , NF-κB , Parasite
	8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) a...		Beta Amyloid , NF-κB , Parasite
TP2194L	Neuropeptide Y (scrambled) Acetate	Pro-Neuropeptide Y (scrambled) Acetate,NPY (scrambled) Acetate	Others
	Neuropeptide Y (scrambled) Acetate (Pro-Neuropeptide Y (scrambled) Acetate) is a scrambled peptide of Neuropeptide Y that has been implicated in Alzheimer's disease (AD) and may have neuroprotective effects.		Others
T9379	L-Threonic acid magnesium salt		Others
	L-Threonic acid magnesium salt (L-TAMS) increases synapse density and memory ability in both aged rats and late stage Alzheimer’s disease (AD) model mice.		Others
T77054	Lecanemab	BAN-2401	Beta Amyloid
	Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's ...		Beta Amyloid
T2507	Azeliragon	TTP488	Beta Amyloid , advanced glycation end products
	Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).		Beta Amyloid , advanced glycation end products
T63540	Astrophloxine		Beta Amyloid
	Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.		Beta Amyloid
TN1472	Cassiaside		Beta-Secretase , BACE
	Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (...		Beta-Secretase , BACE
T60150	(1S,2R)-Alicapistat		Cysteine Protease
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef...		Cysteine Protease
T9062	CA77.1		Autophagy
	CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).		Autophagy
T60739L	Y13g dihydrochloride	Y13g 2HCl(T60739 Free base)	IL Receptor , AChE
	Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi...		IL Receptor , AChE
T77042	Aducanumab	BIIB037	Beta Amyloid
	Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease...		Beta Amyloid